Is it possible that the crash is caused by an external plugin, in that case? If you inspect the stack trace at the point of the crash, is it in a specific plugin each time?
That’s more strange. Are the audio inputs and outputs both on the MOTU device, or are you using separate devices? It sounds like you’re using the MOTU for both input and output, is that correct?
Can you confirm that you see the same behaviour when building the AudioPluginHost from latest develop?
We pushed a fix for another issue with audio devices on macOS very recently. I don’t know whether it’s exactly the same issue, but perhaps it’s related: