We have encountered a strange problem with AAX plugin in Pro Tools.
The playback (without recording or input monitoring) is crackling if the project bit depth is 16 bits but not when it is 24 bits. The sample rate does not affect this only the bit depth. No problems when recording, only when playing back.
Just tested my Juce-based AAX plugin in Pro Tools Ultimate 2018.7.0 on Windows 10 (latest updates), and I could switch my Session setup between 16-bit and 24-bit without any problems.